123I-ADAM SPET imaging of serotonin transporter in patients with epilepsy and comorbid depression
نویسندگان
چکیده
منابع مشابه
123I-ADAM SPET imaging of serotonin transporter in patients with epilepsy and comorbid depression
BACKGROUND Purpose of the study was to investigate alterations in midbrain serotonin transporter (SERT) binding in patients with epilepsy and symptoms of depression compared to patients with epilepsy with no symptoms of depression. METHODS We studied 12 patients with epilepsy (7 patients had focal and 5 had generalized epilepsy syndromes). The presence of self-reported symptoms of depression ...
متن کاملSerotonin transporter binding of [123I]ADAM in bulimic women, their healthy twin sisters, and healthy women: a SPET study
BACKGROUND Bulimia Nervosa (BN) is believed to be caused by an interaction of genetic and environmental factors. Previous studies support the existence of a bulimia-related endophenotype as well as disturbances in serotonin (5-HT) transmission. We studied serotonin transporter (SERT) binding in BN, and to investigate the possibility of a SERT-related endophenotype for BN, did this in a sample o...
متن کامل123I-ADAM binding to serotonin transporters in patients with major depression and healthy controls: a preliminary study.
UNLABELLED The serotonergic system may play an important role in the pathophysiology of major depressive disorder (MDD). Few imaging studies have examined serotonin transporter (SERT) binding in patients with MDD. We hypothesized that SERT binding activity may be altered in patients with MDD. This study compared SERT binding in patients with MDD with that in healthy controls. METHODS We studi...
متن کاملEvaluation of the Serotonin Transporter Ligand 123I-ADAM for SPECT Studies on Humans.
UNLABELLED Imaging serotonin transporters in the living human brain is important in several fields, such as normal psychophysiology, mood disorders, eating disorders, and neurodegenerative disorders. The aim of this study was to compare different kinetic and semiquantitative methods for assessing serotonin transporters using (123)I-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenyla...
متن کاملCentral serotonin transporter availability measured with [123I]beta-CIT SPECT in relation to serotonin transporter genotype.
OBJECTIVE A functional polymorphism has been described in the promoter region of the gene (SLC6A4) coding for the serotonin transporter protein (SERT). This polymorphism has two common alleles, designated as long and short. Each allele has been linked with a number of human clinical phenotypes, including neuropsychiatric diseases associated with dysregulation of serotonin transmission. In vitro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Neurology
سال: 2013
ISSN: 1471-2377
DOI: 10.1186/1471-2377-13-204